Status:
COMPLETED
The Effects of Insulin Detemir and Gliclazide-MR Treatments on Endothelial Functions in Patients With Type 2 Diabetes
Lead Sponsor:
Ankara University
Collaborating Sponsors:
Hacettepe University
The Scientific and Technological Research Council of Turkey
Conditions:
Type 2 Diabetes Mellitus
Eligibility:
All Genders
20-65 years
Phase:
NA
Brief Summary
The main purpose of this study is to analyze the effects of the addition of sulfonylurea (gliclazide MR) or ,alternatively, basal insulin (insulin detemir) to life-style modification and metformin tre...
Detailed Description
The lack of enough number of randomized and controlled studies in the treatment of type 2 diabetes is the most important obstacle in recommending a single-drug or a combination treatment to the other....
Eligibility Criteria
Inclusion
- Type 2 diabetic patients using at least 1000 mg/day metformin at least for 3 months
- 7\<A1C ≤ 11
- Patients without any previous use of oral antidiabetics other than metformin or insulin
- Between 20 to 65 years old male or female patients
Exclusion
- Active hepatic disease
- Serum creatinin 1,5 mg/dl or more for males, 1,4 or more for females
- Proliferative Diabetic Retinopathy
- Coronary Artery Disease
- Patients with any kind of diagnosed malignancy
- Pregnancy and Lactation
- Fasting C-peptide levels lower than 2.0 ng/ml
- Smoking or drug abuse
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT01420692
Start Date
June 1 2010
End Date
June 1 2012
Last Update
August 14 2012
Active Locations (1)
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1
Ankara University Medical Faculty Dept. of Endocrinology and Metabolism
Ankara, Turkey (Türkiye), 06100