Status:
UNKNOWN
Biomarkers in Samples From Adult Patients With Acute Myeloid Leukemia Who Failed Existing Standard-of-Care Treatment
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Leukemia
Eligibility:
All Genders
18-65 years
Brief Summary
RATIONALE: Studying samples of bone marrow and blood from patients with cancer who failed treatment may help doctors learn more about changes that occur in DNA and identify biomarkers related to cance...
Detailed Description
OBJECTIVES: * Define a "non-response" signature that will help up-front identification of cases of intermediate-risk acute myeloid leukemia (AML) destined to fail existing standard-of-care therapy. *...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Samples from previously untreated non-M3 acute myeloid leukemia (AML)
- Normal karyotype (NK) intermediate-risk disease
- Two or more vials of cryopreserved pretreatment bone marrow cells and/or two or more vials of cryopreserved pretreatment blood cells available from the Intergroup AML Repository
- Blast count ≥ 60%
- Eligible and evaluable for the patient's clinical trial, and did not have fatal induction toxicity
- Response to protocol induction chemotherapy:
- Non-response: AML with failure to achieve a complete remission (CR) after induction chemotherapy ("7 \& 3"-based therapy using cytatabine and/or daunorobicin hydrochloride (DNR) OR idarubicin and/or DNR
- Responders: continued complete remission (CCR) \> 2 years
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
September 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT01421862
Start Date
September 1 2011
Last Update
July 10 2013
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