Status:
COMPLETED
Extracorporeal CO2 Removal in COPD Exacerbation
Lead Sponsor:
University of Turin, Italy
Conditions:
COPD Exacerbation
Eligibility:
All Genders
18-90 years
Phase:
PHASE2
Brief Summary
The minimally invasive extracorporeal carbon dioxide removal may decrease the respiratory load during chronic obstructive pulmonary disease (COPD) exacerbation, reducing the need to advance the respir...
Eligibility Criteria
Inclusion
- COPD
- severe acute respiratory failure
- after at least two hours of continuous application of non-invasive ventilatory support (NIV):
- arterial pH ≤7.30 with an arterial pressure of CO2 (PaCO2) \>20% of the baseline value and one of the following:
- respiratory rate ≥30 breaths/min;
- use of accessory muscles or paradoxical abdominal movements
Exclusion
- failure to obtain consent
- hemodynamic instability (MAP \< 60 mmHg) despite infusion of vasoactive drugs
- contraindications to the administration of i.v. heparin (heparin induced thrombocytopenia, hemorrhage, etc.)
- body weight \>120 kg
- contraindication to continuation of active treatment (DNR)
Key Trial Info
Start Date :
May 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01422681
Start Date
May 1 2011
End Date
December 1 2013
Last Update
January 22 2014
Active Locations (1)
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1
University of Turin, Department of Anesthesia and Intensive Care Medicine
Turin, Italy, Italy, 10126