Status:
COMPLETED
Brain Circuits in Schizophrenia and Smoking
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
12-80 years
Brief Summary
The principle aim of the project is to identify the key brain circuits associated with smoking and especially smoking in high risk population. The investigators hope that the study will provide concre...
Detailed Description
There are several studies and hypotheses to be tested. This project includes (1) a cross-sectional study design that measures brain imaging, smoking, clinical diagnosis and symptoms, cognitive functio...
Eligibility Criteria
Inclusion
- Male and Female between ages 12-above (clinical assessments and blood draw only above 62)
- Ability to give written assent (age below 18)
- Ability to give written informed consent (age 18 or above)
- Individuals fulfilled other criteria but over age 62, with major medical illnesses, significant alcohol or other drug use, or unable to undergo MRI may participate in clinical assessments and blood draw if his/her participation forms a family unit (i.e., if at least one of the family member has participated).
- Subjects above age 62 will not participate in MRI measurements although they may still participate in clinical assessments and blood draw.
Exclusion
- Inability to sign informed consent/assent
- For patient participants, Evaluation to Sign Consent (ESC) below 10.
- Any major medical illnesses that may affect normal brain functioning. Examples of these conditions include, but not limited to, stroke, repeated seizure, history of significant head trauma, CNS infection or tumor, other significant brain neurological conditions.
- Significant alcohol or other drug use (substance dependence within 6 months or substance abuse within 1 month) other than nicotine or marijuana dependence.
- Woman who are pregnant (child-bearing potential but not on contraceptive and missing menstrual period; or by self-report; or by positive urine pregnancy test before MRI)
- Can not refrain from using alcohol and/or marijuana 24 hours or more prior to experiments.
- For MRI, unable to undergo MRI scanning due to metallic devices or objects (cardiac pacemaker or neurostimulator, some artificial joints, metal pins, surgical clips or other implanted metal parts) or claustrophobic to the scanner
Key Trial Info
Start Date :
December 20 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2021
Estimated Enrollment :
837 Patients enrolled
Trial Details
Trial ID
NCT01425684
Start Date
December 20 2010
End Date
April 1 2021
Last Update
May 3 2021
Active Locations (1)
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1
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine
Baltimore, Maryland, United States, 21228