Status:
TERMINATED
Effect of Magnesium Sulfate Infusion Rate on Magnesium Retention in Critically Ill Patients
Lead Sponsor:
CAMC Health System
Collaborating Sponsors:
Sarah & Pauline Maier Foundation, Inc.
Conditions:
Primary Hypomagnesemia (Disorder)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Hypomagnesemia (low magnesium) is an electrolyte imbalance commonly found in up to 65% of critically ill patients. Possible consequences of hypomagnesemia include neuromuscular and neurologic dysfunct...
Detailed Description
Hypomagnesemia is a common electrolyte disturbance that affects up to 65% of intensive care unit (ICU) patients with normal renal function. Causes of hypomagnesemia are attributed to either gastrointe...
Eligibility Criteria
Inclusion
- Medicine ICU service patients
- \> 18 years old with
- hypomagnesemia defined by a serum magnesium level \< 2 mg/dL and the clinical decision by the rounding team to replace with parenteral magnesium sulfate
- must have an available IV line for magnesium infusion that may be used for up to 8 hours
- must have a Foley catheter
Exclusion
- renal dysfunction defined by an estimated creatinine clearance (CrCl) \< 30 mL/min or have had an average of \< 0.5 mL/kg/hr of urine output over the previous 12 hours before the magnesium infusion is to begin
- Subjects must not have received a loop diuretic within the 12 hours prior to magnesium replacement and will further be excluded if they receive these medications during the magnesium replacement and urine collection time period
- Subjects with ostomies or acute diarrhea will be excluded due to the possibility of high gastrointestinal magnesium loss
- Subjects will be excluded if they have a physician order for magnesium sulfate to be infused over a specified time period
- If subjects are expected to be moved out of the ICU within the next 24 hours, they will not be considered for randomization due to potential lack of appropriate urine magnesium collection and follow up
- Each subject may only be enrolled in the study for one occurrence of hypomagnesemia
Key Trial Info
Start Date :
April 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01426165
Start Date
April 1 2011
End Date
December 1 2012
Last Update
February 4 2014
Active Locations (1)
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1
Charleston Area Medical Center
Charleston, West Virginia, United States, 25301