Status:
COMPLETED
Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension
Lead Sponsor:
University of Zurich
Conditions:
Pulmonary Hypertension
Breathing-Related Sleep Disorder
Eligibility:
All Genders
20-80 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to study the differential short-term effect of nocturnal oxygen, acetazolamide tablets and nocturnal non-invasive positive pressure ventilation on symptoms, exercise capac...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- percapillary pulmonary hypertension diagnosed by right heart catheterisation -- stable therapy and clinical condition for at least 4 weeks
- sleep disordered breathing with apnea/hypopnea index \> 10 events/h and/or median nocturnal oxygen saturation \<90%
- Exclusion criteria:
- Pregnancy
- severe daytime hypoxemia (PaO2 \< 7.2 kPA)
- patients with predominantly obstructive sleep apnea.
Exclusion
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT01427192
Start Date
November 1 2010
End Date
December 1 2012
Last Update
December 12 2012
Active Locations (1)
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1
Respiratory Clinic, University Hospital of Zurich
Zurich, Canton of Zurich, Switzerland, 8091