Status:
UNKNOWN
PRISM Cardiac Resynchronisation Therapy (CRT) Randomised Controlled Trial
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Cardiac resynchronisation therapy (CRT) is an established treatment for improving symptoms in patients with congestive heart failure (CHF) by left ventricular (LV) pacing. CRT can help to improve LV f...
Eligibility Criteria
Inclusion
- \>18yrs of age
- Standard indication for CRT=P or CRT=D according to NICE criteria (Clinical symptoms of heart failure despite medical therapy, broad QRS \>120ms and significant LV dysfunction LEF \<35%)
- Stable on optimal medical therapy for at least 3 months
- No exclusion to pacing /ICD
- Ischaemic or non-ischaemic aetiology
Exclusion
- Any contraindication to pacing /ICD implant
- Contraindication to MR scanning
- Claustrophobia
- Significant renal impairment (estimated GFR \<30)
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2014
Estimated Enrollment :
270 Patients enrolled
Trial Details
Trial ID
NCT01429753
Start Date
October 1 2011
End Date
April 1 2014
Last Update
September 7 2011
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