Status:
COMPLETED
Identification the Cause of Silent Cerebral infarctiON in Healthy Subjects (ICONS)
Lead Sponsor:
Samsung Medical Center
Conditions:
Cerebral Infarction
Eligibility:
All Genders
20+ years
Brief Summary
We hypothesized that paradoxical embolism may be one of the main mechanisms of silent cerebral infarction (SCI) located outside the perforating artery territory. In the present study, we evaluated the...
Eligibility Criteria
Inclusion
- Healthy subjects
- Subjects with age over 20 years
- Subjects who consecutively visited a health promotion center for a health screening examination that included routine laboratory test, cardiac work-ups (12-lead electrocardiography and/or echocardiography), and brain magnetic resonance image (MRI) and MR angiography (MRA)
- Subjects who showed silent brain infarction (SCI) which was defined as a focal hyperintensity lesion 3 mm or large in diameter in the fluid-attenuation inversion recovery (FLAIR) images without a history of a corresponding stroke or transient ischemic attack (TIA)
- Subjects who performed agitated saline transcranial Doppler (TCD) monitoring
- Patients with acute stroke (both cryptogenic embolic stroke and conventional stroke mechanisms)
- Patients with age over 20 year
- Patients with focal neurologic deficits presented within 7 days of symptom onset
- Patients with acute ischemic lesions on diffusion-weighted image (DWI)
- Patients who performed agitated saline TCD monitoring
Exclusion
- Healthy subjects
- Subjects with the presence of previous history of stroke or TIA
- Subjects with the presence of dementia on history taking or mini-mental status examination
- Subjects with the presence of proximal source of embolism, including atrial fibrillation or significant (≥50%) stenosis on cervicocerebral artery on MRA or carotid Duplex
- Subjects who had SCI restricted within perforator territory (basal ganglia or pons) suggesting that microangiopathy rather than embolism could be the main mechanism of SCI
- Subjects in whom agitated saline TCD monitoring was not performed or those who had poor temporal windows
- Patients with acute stroke (both cryptogenic embolic stroke and conventional stroke mechanisms)
- Patients in whom agitated saline TCD monitoring was not performed or those who had poor temporal windows
Key Trial Info
Start Date :
April 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
581 Patients enrolled
Trial Details
Trial ID
NCT01429948
Start Date
April 1 2008
End Date
May 1 2011
Last Update
September 7 2011
Active Locations (1)
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1
Samsung Medical Center, Sungkyunkwan University
Seoul, South Korea, 135710