Status:
COMPLETED
Analgesic Effect of Escitalopram in Total Knee Arthroplasty (TKA)
Lead Sponsor:
Hvidovre University Hospital
Collaborating Sponsors:
Lundbeck Foundation
Conditions:
Postoperative Pain
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Pain is a major problem after TKA, especially in patients with high pain catastrophizing. Newer MR-scan studies indicate that Escitalopram may have an immediate cognitive and emotional effect. The inv...
Detailed Description
Pain is a major problem after TKA, especially in patients with high pain catastrophizing. Newer MR-scan studies indicate that Escitalopram may have an immediate cognitive and emotional effect. Patient...
Eligibility Criteria
Inclusion
- Primary, unilateral total knee arthroplasty (TKA)
- Age \> 18 \> 81
- Ethnic Danes
- Score \> 20 on Pain Catastrophising Scale
Exclusion
- Medication that causes risk in combination with SSRI (6 month)
- Treatment for anxiety or depression
- History of depression or mania
- Treatment with systemic glucocorticoids (6 month)
- Treatment with opioids (4 weeks)
- Alcohol or drug abuse
- History of malignancy
- Fertile woman
- History of epilepsia
- Treatment with anticoagulants
- BMI \> 40
- Disease affecting central or peripheral nerve function
- Dementia
- History of gastrointestinal bleeding
- History of hepato- or renal insufficiency
- Allergy to Escitalopram
Key Trial Info
Start Date :
September 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT01430520
Start Date
September 1 2011
End Date
May 1 2013
Last Update
June 5 2013
Active Locations (3)
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1
Gentofte Hospital
Gentofte Municipality, Hellerup, Denmark, 2900
2
Regionshospitalet Holstebro
Holstebro, Holstebro, Denmark, 7500
3
Vejle Sygehus
Vejle, Vejle, Denmark, 7100