Status:
COMPLETED
Does Vibration Therapy Induce Higher Than Normal Bone Strains and Strain Rates Than Those Experienced During Habitual Daily Activities
Lead Sponsor:
Sheffield Teaching Hospitals NHS Foundation Trust
Collaborating Sponsors:
University of Sheffield
Conditions:
Osteoporosis
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The overall aim of this study is to test the hypothesis that vibration exercise can induce higher than normal bone strains and strain rates than are experienced during habitual locomotor activities. ...
Eligibility Criteria
Inclusion
- Male or female volunteers, ages 18 to 50 years
- Generally healthy, as determined by review of medical history and physical exam
- Ambulatory
- Willing and physically able to undergo all study procedures
- BMD (measured by DXA) at the lumbar spine and hip within ± 2 SD of the young normal range
- BMI \< 30
Exclusion
- Previous diagnosis of osteoporosis
- History of fracture of the spine, pelvis, leg or foot
- History of bone or joint disorders affecting the shoulders, spine, pelvis, legs or feet (e.g. arthritis, congenital hip dislocation, spinal spondylolisthesis)
- Ongoing conditions or diseases known to cause secondary osteoporosis
- Malabsorption syndromes (e.g. coeliac or Crohn's disease)
- Known disorders of calcium metabolism
- Known history of thyroid disease
- Osteomalacia
- Paget's disease
- Diabetes
- History of cancer within the previous 5 years
- Epilepsy
- Ongoing conditions or use of medications that may impair vision or balance
- Use of the following medications within the previous 2 years
- Bisphosphonates
- Fluoride (except use for oral hygiene)
- Strontium
- Teriparatide
- Other bone agents (e.g. SERMs, isoflavones, HRT, calcitonin etc)
- Steroids
- Alcohol abuse or illicit drug use
- Pregnancy or currently trying to conceive (women only)
- Inability to give informed consent
- Known hypersensitivity to the antibiotic penicillin or cephalosporins
- Known hypersensitivity to the local anaesthetic lignocaine.
Key Trial Info
Start Date :
March 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01430858
Start Date
March 1 2011
End Date
December 1 2012
Last Update
February 15 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Academic Unit of Bone Metabolism
Sheffield, South Yorks, United Kingdom, S5 7AU