Status:
COMPLETED
Wake Therapy in the Treatment of Depression
Lead Sponsor:
New York State Psychiatric Institute
Conditions:
Major Depressive Disorder
Bipolar Disorder
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This pilot study seeks to replicate previous findings that sleep deprivation results in marked improvement in depression symptoms, as well as to test whether concurrent treatment with Light Therapy an...
Detailed Description
Both refractory depression and bipolar depression are difficult to treat. A night of complete sleep deprivation has been shown to result in marked improvement in 60% of depressed patients, although ma...
Eligibility Criteria
Inclusion
- current major depressive episode (MDD, BP-I or BP-II)
- if not BP-I or BP-II, treatment refractory to ≥ 2 adequately used antidepressants having different mechanisms
- If BP-I or BP-II, treatment refractory to ≥ 1 standard treatment, such as lithium or valproate
- physically healthy
- age 18-75
- not taking current antidepressants(antidepressants deemed effective will not be discontinued
Exclusion
- medically unstable condition
- past intolerance of lithium (bipolar only)
- history of (or current) psychosis or epilepsy
- current (past six months) drug or alcohol abuse/dependence
- pregnancy
- contraindication to lithium (bipolar only)
- significant retinal pathology (e.g., retinitis pigmentosa, macular degeneration)
- currently taking effective antidepressant
- cognitive dysfunction
- Parkinson's Disease
- Thyroid Stimulating Hormone \> 5 milli International Units/Liter
- left ventricular hypertrophy
- symptomatic mitral valve prolapse
- abnormal creatinine
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2016
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT01431573
Start Date
July 1 2011
End Date
August 1 2016
Last Update
March 18 2021
Active Locations (2)
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1
Depression Evaluation Service - New York State Psychiatric Institute
New York, New York, United States, 10032
2
New York State Psychiatric Institute
New York, New York, United States, 10032