Status:
COMPLETED
Systemic Dickkopf-related Protein 1 (DKK1)During Estrogen Level Changes in Post-menopausal Breast Cancer Patients Treated With Aromatase Inhibitors
Lead Sponsor:
University of Arkansas
Conditions:
Breast Cancer
Eligibility:
FEMALE
18+ years
Brief Summary
The investigators are hypothesizing that decreasing estrogen levels will cause serum DKK1 to peak, then decrease gradually as estrogens reach a new lower, but steady level. The investigators also beli...
Eligibility Criteria
Inclusion
- Post Menopausal Breast cancer patients with planned treatment of aromatase inhibitors.
- 18 years or older
Exclusion
- BMI \>30 or \<18
- Osteoporosis as defined by protocol.
- Subjects currently on bisphosphonate therapy.
- History of primary or secondary hyperparathyroidism
- History of Hypo-or Hyperthyroidism
- History of Vitamin D levels below LLN
- History of creatinine clearance below the EGFR
- History ofLiver function tests above 1.5 times ULN including LDH, SGOT, SGPT, Alkaline phosphatase, and Bilirubin
- History of documented cirrhosis of the liver
- History of chronic heparin use
- History of chronic glucocorticoid therapy
Key Trial Info
Start Date :
April 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT01431872
Start Date
April 1 2011
End Date
August 1 2015
Last Update
November 4 2015
Active Locations (1)
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1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72120