Status:
COMPLETED
Diagnostic Accuracy of Whole Body Magnetic Resonance Imaging in Inflammatory Myopathies
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Myositis
Polymyositis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Idiopathic inflammatory myopathies (IIM) are a great concern in acquired muscle illnesses. An appropriate and rapid diagnosis is necessary, because morbidity and mortality are high and a specific trea...
Detailed Description
Idiopathic inflammatory myopathies (IIM) are a great concern in acquired muscle illnesses. An appropriate and rapid diagnosis is necessary, because morbidity and mortality are high and as a specific t...
Eligibility Criteria
Inclusion
- Skin rash typical of dermatomyositis: "lilac" rash (+/- oedemata) of upper eyelids, periungual sign, erythematous-scaly eruption occurring over the MCP and IPP, elbow, knees (Gottron's signs ands papules), erythema of light-sensitive areas OR
- Muscle weakness which is proximal, bilateral and objectifiable by clinical examination ≤ 4/5, and CPK≥2N (N\<170).
- Increase CPK and presence of acquired myositis specific antibody
- AND
- Onset of troubles ≤3 years
Exclusion
- Pregnant female
- Proximal motive neuropathy
- Refusing participation
- Patient under 18 years old
- Adult patient under legal protection
- Patient with contraindication for MRI, pacemaker
- For all other magnetic or ironic implanted equipments, metal workers, must contact PI to ensure their eligibility
- Ocular muscles weakness, isolated dysarthria,
- Patients suffering from toxic myopathy, amyloidosis, inherited muscular dystrophy
Key Trial Info
Start Date :
December 22 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 26 2016
Estimated Enrollment :
139 Patients enrolled
Trial Details
Trial ID
NCT01432613
Start Date
December 22 2010
End Date
November 26 2016
Last Update
March 2 2018
Active Locations (1)
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1
CHU Amiens Nord
Amiens, France, 80054