Status:
COMPLETED
Short-term Changes on C-Reactive Protein (CRP) Levels After Non-surgical Periodontal Treatment
Lead Sponsor:
State University of Maringá
Conditions:
Chronic Periodontitis
Atherosclerotic Cardiovascular Disease
Eligibility:
All Genders
35-75 years
Phase:
NA
Brief Summary
The hypotheses tested were that levels of C-Reactive Protein (CRP) would be higher in patients with chronic periodontitis in comparison with those without periodontal disease and that the non-surgical...
Eligibility Criteria
Inclusion
- Patients should have ≥ 20 teeth present; (ii) absence of oral soft tissue lesions; (iii) have ≤ 3 carious lesions in all teeth. In addition, to be included in the Test group the subject had to present chronic periodontitis (involvement of at least 5 teeth with at least one site presenting probing depth (PD) ≥ 5 mm and clinical attachment loss (CAL) ≥ 3 mm) while to be included in the Control group the patient had to exhibit periodontal healthy (bleeding on probing (BOP) \< 30% of the sites and absence of any PD \> 4mm associated with BOP).
Exclusion
- (i) periodontal disease treatment in the previous six months; (ii) aged less than 35 years; (iii) systemic conditions such as history of CVD or any other chronic or immunologic diseases and the use of related drugs in the previous six months; (iv) smokers or former smokers; (v) pregnant or lactating women; (vi) hypertension (\>140 systolic and \> 90 diastolic mmHg); (vii) obesity (Body Mass Index (BMI) ≥ 30 kg/m²); (viii) levels of HDL-cholesterol \> 35.0 mg/dL (ix) levels of LDL-cholesterol \< 160.0 mg/dL (x)levels of triglycerides \< 400.0 mg/dL and (xi) levels of glucose levels \< 100 mg/dL.
Key Trial Info
Start Date :
January 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT01433744
Start Date
January 1 2010
End Date
July 1 2011
Last Update
September 14 2011
Active Locations (1)
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1
Departament of Dentistry of State University of Maringá
Maringá, Paraná, Brazil, 87080000