Status:
COMPLETED
Performance Evaluation of Four Pharmacokinetic-Pharmacodynamic(PKPD) Models of Propofol in Elderly Patients
Lead Sponsor:
Universidad del Desarrollo
Collaborating Sponsors:
Pontificia Universidad Catolica de Chile
Conditions:
Propofol Overdose of Undetermined Intent
Eligibility:
All Genders
65+ years
Brief Summary
Despite the wide use of propofol target-controlled infusion (TCI) in elderly patients, pharmacokinetic (PK) and pharmacodynamic (PD) models performance has not been prospectively assessed in this popu...
Detailed Description
After BIS® and routine monitors were placed, 14 ASA I-II elderly patients (\>65 yr) will be anesthetized with plasma TCI of propofol based on Schnider model. After partial recovery from a bolus dose a...
Eligibility Criteria
Inclusion
- Patients older than 65 years, ASA 1,2
Exclusion
- Included less than 70% or more than 130% of ideal body weight
- Neurologic disorder
- Use of psychoactive medication, including alcohol intake during the last 48 hours
Key Trial Info
Start Date :
April 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT01435785
Start Date
April 1 2011
End Date
December 1 2011
Last Update
March 29 2017
Active Locations (2)
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1
Clinica Alemana de Santiago
Santiago, Chile, 76534
2
Clinica Alemana Santiago
Santiago, Chile, 76534