Status:
TERMINATED
Effective Study of Preoperative Short-course Radiotherapy for the Advanced Resectable Rectal Cancer
Lead Sponsor:
West China Hospital
Conditions:
Rectal Neoplasms
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
PHASE3
Brief Summary
The local recurrence of rectal cancer is one of the main problem that fail the treatment. The preoperative neoadjuvant (chemo)radiotherapy has been confirmed to reduce the local recurrence rate,especi...
Detailed Description
The colorectal cancer is the secondary most common cancer among the population. Every year,it's estimated that there was over 1,200,000 new cases,and in China the data is about 440,000. The local recu...
Eligibility Criteria
Inclusion
- histologically verified adenocarcinoma of the rectum;
- the lower border of the tumor within 10cm of the anal verge;
- age between 18 to 80 years;
- preoperative endosonography,MRI and the abdominopelvic CT diagnosis as advanced rectal cancer (cT3/N+)(the detail of these two subgroup was illustrated in the detailed description of this trial);
- ECOS ≤ 2
- there was no evidence of metastasis with chest and abdominopelvic CT.
Exclusion
- with other colorectal cancer, or other cancer,simultaneously;
- Locally recurrent rectal cancer;
- had a history of malignant tumor within 5 years(except the skin cancer);
- Pregnant or lactating women
- there was contraindication for the preoperative adjuvant radiotherapy or the operation.
- with antitumor drug or radiation before this trial.
- discovery of metastasis in the operation
- worrying about the local recurrence or the adverse effect of the radiation excessively;
- with mental disorder.
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2020
Estimated Enrollment :
410 Patients enrolled
Trial Details
Trial ID
NCT01437514
Start Date
August 1 2011
End Date
December 1 2020
Last Update
June 7 2021
Active Locations (4)
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1
Sichuan academy of medical science and sichuan provincial people's hospictal
Chengdu, Sichuan, China, 610000
2
the Third People'S Hospital of Chengdu
Chengdu, Sichuan, China, 610000
3
West China hospital, Sichuan University
Chengdu, Sichuan, China, 610000
4
The Third Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China