Status:
UNKNOWN
KL-6 Protein as a Biomarker of Lung Injury in Viral Bronchiolitis
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Acute Viral Bronchiolitis
Eligibility:
All Genders
1-1 years
Brief Summary
Serum KL-6 protein has been described as a biomarker of epithelial lung injury in Respiratory Syncytial Virus bronchiolitis. The investigators can imagine that epithelial injury intensity has conseque...
Detailed Description
Prospective, monocentric, case-control and transversal study Primary end-point: correlation between serum KL-6 level and severity of the bronchiolitis, evaluated by a clinical scoring system establish...
Eligibility Criteria
Inclusion
- Cases: Inaugural acute bronchiolitis in infant aged under 1 year; bronchiolitis is defined by rhinorrhea and/or cough, dyspnea, associated with clinical or radiological distension, wheezing or crackling or brake expiratory.
- Controls: Infant aged under 1 year with blood sample test performed for a non-infectious disease (preoperative assessment)
Exclusion
- Cases: bronchopulmonary dysplasia, prematurity, cystic fibrosis, immunodeficiency, primary ciliary dyskinesia, congenital cardiopathy, use of corticotherapy the week between inclusion
- Controls: infectious documented disease, respiratory symptoms
Key Trial Info
Start Date :
October 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2016
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01437956
Start Date
October 1 2011
End Date
October 1 2016
Last Update
September 21 2011
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