Status:
COMPLETED
Closed Loop Glucose Control in Intensive Care Unit
Lead Sponsor:
University of Cambridge
Collaborating Sponsors:
European Commission
Cambridge University Hospitals NHS Foundation Trust
Conditions:
Stress Hyperglycaemia
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to assess the efficacy, safety and feasibility of a computer-based control algorithm to control glucose levels in adults in intensive care unit, in comparison to standard ...
Detailed Description
This will be a single centre, open-label, randomised, parallel design, feasibility study conducted at Neurosciences Critical Care Unit (NCCU), Addenbrooke's hospital, Cambridge, UK. Study will aim for...
Eligibility Criteria
Inclusion
- Aged 18 years and older
- Admitted to Neurosciences critical care unit; (all patients are eligible regardless of admitting diagnosis except where specified under exclusion criteria)
- Stay in intensive care unit expected to be at least 48 hours
- At least one of the following conditions applies:
- Not on insulin infusion and single confirmed reference blood glucose level \> 10.0 mmol/l
- Already on insulin infusion including those subjects with pre-existing diabetes.
Exclusion
- Patients with diabetic ketoacidosis or hyperosmolar hyperglycaemic non-ketotic coma (HONK)
- Patients who are receiving therapeutic hypothermia
- Known or suspected allergy to insulin
- Any disease or condition which the investigator or treating physician feels would interfere with the trial or the safety of the patient (i.e. liver failure, other fatal organ failures)
- Patients with significant abnormalities of blood clotting.
- Moribund patients likely to die within 48 hours
- Pregnancy
Key Trial Info
Start Date :
May 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01440842
Start Date
May 1 2012
End Date
October 1 2012
Last Update
January 3 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital
Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ