Status:
COMPLETED
Analysis of Foxp3 and Vimentin Expression in Renal Transplant Recipient
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Function of Renal Transplant
Eligibility:
All Genders
18+ years
Brief Summary
This observational study is designed to analyse the urinary mRNA expression of Foxp3 and Vimentin, two genes involved in tolerance and early graft dysfunction in 500 renal transplant recipients from 1...
Detailed Description
This observational study is designed to analyse the urinary mRNA expression of Foxp3 and Vimentin, two genes involved in tolerance and early graft dysfunction in 500 renal transplant recipients from 1...
Eligibility Criteria
Inclusion
- All renal transplant recipients aged \>18 years with informed consent
- Kidney transplantation in one of the centers participating in the study all patients registered on the waiting list to the Agency of Biomedicine
- Supported by a conventional procedure
- Informed consent signed.
- No pregnancy or lactation in progress.
- Serology HIV and (HCV negative suppressed by amendment n°2)
- No contraindication for a biopsy at 1 year post transplant
Exclusion
- Positive crossmatch, focal segmental glomerulosclerosis (FSGS) as primary nephropathy, HIV positive population
- Absence of registration on the waiting list for transplantation with the Agency of Biomedicine
- HIV-positive serology
- Chronic renal failure secondary to focal segmental hyalinosis
- Cross-match historical or cross match of the day positive T or B awareness
- Patient included in a Memorandum of industry (suppressed by amendment n°1)
- No affiliation to a social security scheme
- Patients with early failure due to immediate complications (4%) will be included but will not be considered for analysis
Key Trial Info
Start Date :
September 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
266 Patients enrolled
Trial Details
Trial ID
NCT01443013
Start Date
September 1 2010
End Date
January 1 2015
Last Update
October 20 2015
Active Locations (1)
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1
Henri Mondor Hospital
Créteil, France, 94010