Status:
COMPLETED
Metabolic and Inflammatory Responses to Hemodialysis and the Effect of a Meal
Lead Sponsor:
University of Aarhus
Conditions:
Kidney Failure, Chronic
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of this study is to characterize the hormonal and inflammatory responses to hemodialysis, and to determine the effect of a meal versus fast on the metabolic changes in the post-dialytic ...
Detailed Description
Studies show that hemodialysis (HD) is a protein catabolic event per se and probably contributes to the high prevalence of protein-energy wasting among HD patients. The muscle catabolic effect of HD i...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- \> 18 years
- stable maintenance hemodialysis for at least 3 months
- well-functioning arteriovenous shunts with recirculation less than 5%
- informed consent
- Exclusion criteria:
- diabetes mellitus
- body mass index below 18.5 or above 30.0 kg/m2
- malnutrition (global assessment score C)
- active malignant disease
- immunosuppressive treatment (including glucocorticoid treatment)
- evidence of an ongoing inflammatory disease (including infection and autoimmune disorders)
- pregnancy
- Exclusion criteria during the study:
- myocardial infarction or arrythmia with hemodynamic derangements
- permanent thrombosis in the arteriovenous (AV) shunt
- severe infectious disease
- renal transplantation
Exclusion
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01446302
Start Date
October 1 2011
End Date
May 1 2012
Last Update
August 14 2012
Active Locations (2)
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1
Department of Nephrology, Aarhus University Hospital, Skejby
Aarhus N, Denmark, 8200
2
Department of Nephrology, Viborg Regional Hospital
Viborg, Denmark, 8800