Status:
UNKNOWN
The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)
Lead Sponsor:
M.D. Anderson Cancer Center
Conditions:
Bladder Cancer
Colorectal Cancer
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this study is to understand factors which may influence risk for colorectal and other cancers in families. These factors include genetic variability, in combination with diet and lifestyle...
Detailed Description
If you agree to take part in this study, you will have a single sample (8-10 teaspoons) of blood collected, depending upon current health status. The blood will be drawn at MD Anderson. If you cannot ...
Eligibility Criteria
Inclusion
- All patients with a new referral for a diagnosis of colorectal cancer (adenocarcinoma) and/or HNPCC-related cancers at the UTMDACC will be considered potentially eligible for this study regardless of prior treatment.
- Families maintained at the UTMDACC Hereditary Colon Cancer Registry that have a known germline mutation in a mismatch repair gene or contain two or more first degree relatives diagnosed with CRC and/or any HNPCC-related cancers, one of whom must be less than or equal to 50 years at diagnosis.
- First-degree and more distant relatives of individuals diagnosed with CRC and/or any HNPCC-related cancers from either of the groups in 1 and 2 (above).
- Any patient diagnosed with CRC and/or any HNPCC-related cancers less than or equal to 45 years of age.
- Greater than or equal to age 18 at time of study.
- Able to provide informed consent to participate in this study indicating that they are aware of the investigational nature, in keeping with the policies of this hospital.
- Non-HNPCC quartets, defined as parents and two offspring who do not carry a mismatch repair gene mutation. These non-HNPCC quartets should have no personal history of cancer, nor cancer in any first degree relatives of the quartet members, nor history of trinucleotide repeat syndromes. Non-HNPCC parents in a quartet should be less than 34 years old at the time the offspring were born.
- Lynch Syndrome patients identified and recruited through Protocol PA11-0567 who opt into Optional Procedure B, which consents the patient to participate in this study.
Exclusion
- Diagnosis of current major psychiatric disorder, per DSM-III-R (or DSM IV).
- Age less than 18 years at time of enrollment.
Key Trial Info
Start Date :
September 1 1994
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2020
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT01447199
Start Date
September 1 1994
End Date
September 30 2020
Last Update
January 7 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030