Status:
UNKNOWN
Indocyanine Clearance Rate and Septic Liver Injury
Lead Sponsor:
Sun Yat-sen University
Conditions:
Sepsis
Eligibility:
All Genders
18+ years
Brief Summary
Liver injury is a complication of sepsis and septic liver injury has adverse impact upon the outcome. As a measurement for liver function, Plasma clearance rate of indocyanine green (PDR-ICG) always d...
Detailed Description
Liver injury is a complication of sepsis and septic liver injury has adverse impact upon the outcome. However, changes of transaminase or bilirubin are always not significant during the early phase of...
Eligibility Criteria
Inclusion
- For control group: the patient does not match the diagnosis criteria of sepsis before the operation; the operation was done in peritoneal cavity; the patient is transferred to SICU directly from surgical room or recovery room; the patient is anticipated to stay in SICU for more than 48 hours.
- For study group: the patient matches the diagnosis criteria of sepsis; the patient is anticipated to stay in SICU for more than 48 hours.
Exclusion
- Pregnancy
- Age \< 18 years
- The infection is purely caused by virus
- Obstruction of biliary tract, or acute cholangitis, or acute liver abscess, or active hepatitis, or hyperacute/acute liver rejection occurs during study period
- Hemorrhagic shock occurs during study period
- Asthma occurs during study period
- Acute coronary syndrome occurs during study period
- Continuing peripheral circulation dysfunction leads to refractory "low quality" during PDR-ICG measurement
- Comorbidity of the bladder leads to impossibility to measure intra-abdominal pressure
Key Trial Info
Start Date :
July 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2012
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01447836
Start Date
July 1 2011
End Date
November 1 2012
Last Update
October 6 2011
Active Locations (1)
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1
Surgical Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510080