Status:

COMPLETED

A Phase Ib Study of MEK162 Plus BYL719 in Adult Patients With Selected Advanced Solid Tumors

Lead Sponsor:

Array BioPharma

Conditions:

Advanced and Selected Solid Tumors

AML

Eligibility:

All Genders

18+ years

Phase:

PHASE1

Brief Summary

This is a multi-center, open-label, dose-finding, phase Ib study to estimate the maximum tolerated dose(s) (MTD(s)) and/or recommended dose(s) for expansion (RDE(s)) for the orally administered combin...

Eligibility Criteria

Inclusion

  • Histologically/cytologically confirmed, advanced solid tumors, AML or high risk and very high risk MDS
  • Measurable disease as determined by RECIST 1.1

Exclusion

  • Primary CNS tumor or CNS tumor involvement
  • Diabetes mellitus
  • Unacceptable ocular/retinal conditions
  • Clinically significant cardiac disease or impaired cardiac function

Key Trial Info

Start Date :

March 1 2012

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

August 15 2017

Estimated Enrollment :

139 Patients enrolled

Trial Details

Trial ID

NCT01449058

Start Date

March 1 2012

End Date

August 15 2017

Last Update

October 2 2017

Active Locations (16)

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Page 1 of 4 (16 locations)

1

University of California San Diego - Moores Cancer Center Dept Onc

La Jolla, California, United States, 92093-0658

2

H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt SC

Tampa, Florida, United States, 33612

3

Northwestern Memorial Hospital

Chicago, Illinois, United States, 60611

4

Massachusetts General Hospital CCPO

Boston, Massachusetts, United States, 02114