Status:
COMPLETED
Evaluation in the Treatment of Nosocomial Sepsis Comparing Polymerase Chain Reaction With Conventional Blood Culture.
Lead Sponsor:
Instituto do Coracao
Collaborating Sponsors:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conditions:
Sepsis
Bacteremia
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
The objective of this study is to evaluate the consumption of antimicrobial therapy in patients comparing a rapid molecular test (PCR in Real-Time Multiplex) with blood cultures to identify the etiolo...
Detailed Description
Patients staying more than 48 hours in hospital with clinical suspicion of sepsis could be included in the study. Blood samples for cultures and multiplex PCR will be collected immediately prior to in...
Eligibility Criteria
Inclusion
- Patient 18 or more years old
- Patient staying more than 48 hours in hospital
- Patient with clinical suspicion of infection and presenting at leat two of the following criteria:temperature \> 38oC or \< 36oC, heart rate \> 90 beats/minute, respiratory rate \> 20 breaths/minute or PaCO2 \< 32 mmHg or leukocytosis \>12 000/μl or leukopenia \<4000/μl or normal white blood cell count with \>10% immature forms
- Patient or responsible able to provide informed consent
Exclusion
- Patient submitted to cardiovascular surgery in the last fifteen days
- Patient or responsible are not able to provide informed consent
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2016
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01450358
Start Date
January 1 2012
End Date
May 1 2016
Last Update
June 9 2016
Active Locations (1)
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1
Instituto do Coracao
São Paulo, São Paulo, Brazil, 05403000