Status:
COMPLETED
Effect of the Kv7-channel Opener Flupirtine on the Excitability of Human Peripheral Myelinated Axons in Vivo
Lead Sponsor:
Ludwig-Maximilians - University of Munich
Conditions:
Axonal Change, Neuronal
Pain
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Slow axonal Kv7 potassium channels are found along unmyelinated axons and at the nodes of Ranvier of myelinated axons in peripheral nerve. As such the pharmacological activation of Kv7 channels offers...
Eligibility Criteria
Inclusion
- voluntarily
- age \> 18 years old
Exclusion
- current use of medication (e.g. analgetics, antiepileptics, antidepressants, etc.)
- prevailing organic disease (e.g. diabetes, vascular or neurologic illness, etc.)
- previous physical trauma of the forearm (e.g. burning, surgery)
- primary organ failure
- pregnancy and lactation
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2010
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01450865
Start Date
October 1 2009
End Date
August 1 2010
Last Update
January 13 2015
Active Locations (1)
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1
Multidisciplinary Pain Unit Department of Anaesthesiology University of Munich Pettenkoferstr. 8a
Munich, Bavaria, Germany, 80336