Status:
COMPLETED
Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Cantonal Hospital of St. Gallen
Kantonsspital Münsterlingen
Conditions:
Thoracic Surgery
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Desflurane and its effect on postoperative morbidity and mortality in patients undergoing thoracic surgery. Halothane, enflurane, isoflurane, sevoflurane, and desflurane are volatile anesthetics, a g...
Eligibility Criteria
Inclusion
- Inclusion criteria: • Elective thoracic surgery (thoracotomy, thoracoscopy)
- Lung resection
- One-lung ventilation
- Adults (18-80 years of age)
- ASA classification I - III
- Written consent (signature from patient)
- Exclusion criteria:
- Known hypersensitivity or suspected allergy to propofol, soja or egg proteins
- Known hypersensitivity to volatile anesthetics (malignant hyperthermia)
- Medication with high dosage of statins
- Therapy with cyclosporin
- Severe renal impairment (GFR \< 30 ml/min)
- Oral steroid treatment at present or stopped less than 3 months before surgery
- Inflammatory processes (non-pulmonary or pulmonary): elevated C-reactive protein level (\> 20 mg/l) or leukocytosis (leukocytes \> 10x103/?l) or body temperature \> 37°C)
- Pregnancy
- Breast feeding
- The subject must not be involved in any other clinical trial during the course of this trial, nor within a period of 30 days prior to its beginning or 30 days after its completion
Exclusion
Key Trial Info
Start Date :
December 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
460 Patients enrolled
Trial Details
Trial ID
NCT01452256
Start Date
December 1 2011
End Date
December 1 2014
Last Update
February 17 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospital Zurich
Zurich, Switzerland