Status:
COMPLETED
Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma
Lead Sponsor:
Hackensack Meridian Health
Conditions:
Multiple Myeloma
Eligibility:
All Genders
18-69 years
Phase:
PHASE2
Brief Summary
The hypothesis for this study is that the regimen consisting of fludarabine, melphalan and bortezomib improves the progression free survival and the response rate compared to historical controls of fl...
Detailed Description
Multiple myeloma is the second most prevalent blood cancer (10%) after non-hodgkin's lymphoma. It represents approximately 1% of all cancers and 2% of all cancer deaths. Although the peak age of onset...
Eligibility Criteria
Inclusion
- Diagnosis of multiple myeloma
- Have a suitable related or unrelated donor
- Age ≥18 but \<70 yrs
- KPS of ≥70%
- Recovery from complications of previous therapies
Exclusion
- Diagnosis other than multiple myeloma
- Chemotherapy or radiotherapy within 21 days of initiating treatment in this study
- Prior dose-intense therapy requiring HSC support within 56 days of initiating treatment in this study
- Uncontrolled bacterial, viral, fungal or parasitic infections
- Uncontrolled CNS metastases
- Known amyloid deposition in heart
- Organ dysfunction
- LVEF \<40% or cardiac failure not responsive to therapy
- FVC, FEV1, or DLCO \<50% of predicted and/or receiving supplementary continuous oxygen
- Evidence of hepatic synthetic dysfunction, or total bilirubin \>2x or AST \>3x ULN
- Measured creatinine clearance \<20 ml/min
- Sensory peripheral neuropathy grade 4 within 14 days of enrollment
- Karnofsky score \<70% unless a result of bone disease directly caused by myeloma
- Life expectancy limited by another co-morbid illness
- Diagnosed or treated for another malignancy within 3 years of enrollment, with the exception of complete resection of basal cell carcinoma or squamous cell carcinoma of the skin, an in situ malignancy, or low-risk prostate cancer after curative therapy
- Female subject is pregnant or breast-feeding (women) or unwilling to use acceptable birth control methods (men or women) for twelve months after treatment. Confirmation that the subject is not pregnant must be established by a negative serum beta-human chorionic gonadotropin (B-hCG) pregnancy test result obtained during screening. Pregnancy testing is not required for post-menopausal or surgically sterilized women.
- Documented hypersensitivity to fludarabine or melphalan or to bortezomib, boron or mannitol or any components of the formulation
- Patients unable or unwilling to provide consent
- Patient has a sustained platelet count of \<30 x 10 9/L within 14 days before enrollment
- Patient has a sustained absolute neutrophil count of \<1.0 x10 9/L within 14 days before enrollment
- Myocardial infarction within 6 months prior to enrollment or has New York Heart Association (NYHA) Class III or IV heart failure uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Prior to study entry, any ECG abnormality at screening has to be documented by the investigator as not medically relevant
- Patient has received other investigational drugs with 14 days before enrollment
- Serious medical or psychiatric illness likely to interfere with participation in this clinical study
Key Trial Info
Start Date :
June 9 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 11 2020
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT01453101
Start Date
June 9 2010
End Date
June 11 2020
Last Update
May 25 2022
Active Locations (1)
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1
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601