Status:
COMPLETED
Transplantation of Autologous Mesenchymal Stem Cell in Decompensate Cirrhotic Patients With Pioglitazone
Lead Sponsor:
Royan Institute
Conditions:
Liver Fibrosis
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
Liver cirrhosis (LC) is the final destiny in chronic liver disease. Liver transplantation is the only effective therapy available to these patients. However, limited number of donors, post surgical co...
Detailed Description
BM Aspiration will be done twice (6 months interval) from the iliac crest according to standard procedures under general anesthesia and is collected (200ML) in plastic bags containing anti coagulant. ...
Eligibility Criteria
Inclusion
- 18-65 Years cirrhotic patient
- Approved cirrhosis by elastografy ,biopsy, sonography
Exclusion
- 1 - Portal vein thrombosis 2-Hepatic encephalopathy, score 3\&4 3-ALT \& AST 3times more than normal 4-Serum Cr more than 1/5mg/dL 5-(Anti-HIV +) (Anti-HCV+) (HBS-Ag+) 6-Hepatocel carcinoma 7- Primary sclerosing cholangitis (PSC) 8- Esophageal varices grade 4 9-Addiction 10-Child Score B,C
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT01454336
Start Date
June 1 2010
End Date
July 1 2013
Last Update
May 13 2014
Active Locations (1)
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1
Royan Institute
Tehran, Iran