Status:
TERMINATED
Optimisation of Antipsychotic Drug Use in Older People
Lead Sponsor:
Institute of Psychiatry, London
Conditions:
Alzheimer's Disease
Schizophrenia
Eligibility:
All Genders
60-95 years
Phase:
PHASE4
Brief Summary
Drugs such as amisulpride, known as antipsychotic drugs, are used to treat troublesome and distressing symptoms in older people. Although these drugs can be beneficial, they are associated with side e...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Treatment and Control (antipsychotic free) Group
- Schizophrenia
- meet diagnostic criteria for schizophrenia-like illness
- aged between 60 and 95 years of age
- score \<6 on the Geriatric depression scale
- Alzheimer's
- meet diagnostic criteria for AD
- score \<=4 on the Modified Hachinski Ischaemia Scale
- score \< 8 on a modified version of the UPDRS
- aged between 60 and 95 years of age
- score \<6 on the Geriatric depression scale
- Exclusion Criteria
- Treatment Group
- Schizophrenia
- current or past history of addiction, traumatic brain injury or epilepsy
- prescribed any drug that interferes with brain dopamine in past 2 weeks (6 weeks if depot antipsychotic medication).
- medical conditions that might affect Ability to tolerate a brain scan
- unable to give informed consent
- Alzheimer's
- current or past history of psychiatric illness, traumatic brain injury or epilepsy
- prescribed an antipsychotic or other oral drug that interferes with brain dopamine function within the past 2 weeks (6 weeks if depot antipsychotic medication).
- medical conditions that might affect a person's ability to tolerate a brain scan
- Control (antipsychotic free) Group
- Schizophrenia
- Prescribed psychotropic medication
- unable to give informed consent
- Alzheimer's
- • Prescribed psychotropic medication
Exclusion
Key Trial Info
Start Date :
May 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT01454453
Start Date
May 1 2012
End Date
July 1 2015
Last Update
April 19 2017
Active Locations (1)
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1
Institute of Psychiatry, Kings College London
London, United Kingdom, SE58AF