Status:
COMPLETED
Study of Postoperative 3D-CRT/IMRT in Hepatocellular Carcinoma
Lead Sponsor:
Chinese Academy of Medical Sciences
Conditions:
Hepatocellular Cancer
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Hepatectomy is difficult when the tumor is adjacent to the big vessels of the liver and some patients can not receive radical resection. Such patients have high risk of recurrence. Tumor resection and...
Detailed Description
Patients with risk factors of recurrence receive postoperative radiotherapy using intensive modulated radiation therapy (IMRT) or three-dimensional conformal radiation therapy (3DCRT). The clinical ta...
Eligibility Criteria
Inclusion
- written informed consent provided
- 18\~75 years old
- patients with histopathological proved hepatocellular carcinoma received hepatectomy and had at least one risk factor of recurrence
- without any lymph node or distant metastasis (any T N0M0)
- liver function: Child-Pugh A or B
- Performance status: Karnofsky (KPS)≥70 or world health organization(WHO) score 0,1
- life expectation\>6 months
- no dysfunction of major organs
- no prior radiotherapy
- negative for human immunodeficiency virus syndrome (HIV)
- Considerable to computed tomography(CT) simulation and 3D-CRT or IMRT
Exclusion
- malignant tumors of other sits
- combining severe diseases, such as acute myocardial infarction(AMI), arrhythmias, infection
- surgery performed in other hospitals without details
- pregnant woman or woman need to breast feed or woman with positive chorionic gonadotrophin (HCG)
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2017
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT01456156
Start Date
January 1 2008
End Date
January 1 2017
Last Update
July 5 2017
Active Locations (1)
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1
Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 100021