Status:
COMPLETED
Intensified Conditioning Regimen With High-Dose-Etoposide for Allo-HSCT for Adult Acute Lymphoblastic Leukemia
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Collaborating Sponsors:
Fujian Medical University Union Hospital
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Conditions:
Acute Lymphoblastic Leukemia
Stem Cell Transplantation, Hematopoietic
Eligibility:
All Genders
14-65 years
Phase:
PHASE2
PHASE3
Brief Summary
Evolving paradigms in the treatment of adult ALL include the application of intense pediatric regimens to the treatment of adolescents and young adults (AYA) and the optimization of allogeneic hematop...
Detailed Description
In the first decade of the new millennium, multiple studies have begun to change our thinking about the treatment of adults with acute lymphoblastic leukemia (ALL). In pediatric patients cure rates in...
Eligibility Criteria
Inclusion
- Age: 14 years to 65 years
- Diagnosis of High-risk acute lymphoblastic leukemia or standard-risk ALL in ≥CR2
- Patient will receive allogeneic hematopoietic stem cell transplantation
- The informed consent form has been signed.
Exclusion
- Patient with severe cardiac dysfunction with less than 50% EF
- Patient with severe lung dysfunction
- Patient with severe hepatic or renal dysfunction with more than 3 times the upper limit of normal range (ULN) of serum ALT or AST levels, or with more than 2 times the upper limit of normal range (ULN) of serum TBIL level or less than 40% of normal prothrombin time activity (PTA); or with more than 2 times the ULN of serum Cr
- Patient with severe active infection
- Patient with allergy history about suspected drug in conditioning regimen
- Patient with other conditions considered unsuitable for the study
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01457040
Start Date
October 1 2011
End Date
December 1 2016
Last Update
October 12 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Hematology, Nanfang Hospital
Guangzhou, Guangdong, China, 510515