Status:
UNKNOWN
Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia
Lead Sponsor:
Seoul National University Bundang Hospital
Conditions:
Cerebral Aneurysm
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The investigators hypothesized that valproic acid will increase rocuronium requirement and MgSO4 infusion would reduce requirement of muscle relaxant in craniotomy patients preloaded with sodium valpr...
Detailed Description
Magnesium sulfate (MgSO4) is known to reduce requirement of muscle relaxant.
Eligibility Criteria
Inclusion
- 18- 65 years
- American society of anesthesiology physical status 1,2
- scheduled for elective craniotomy for aneurysm clipping or for superficial temporal artery-middle cerebral artery anastomosis
Exclusion
- body mass index \<18.5 or \>24.9 kg m-2; neuromuscular, renal, cardiovascular or hepatic insufficiency; Glasgow coma scale (GCS) \<15; allergy to the study drugs; medications influencing NDMRs; breast feeding; pregnancy; and preoperative epilepsy.
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2011
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01460563
Start Date
October 1 2011
End Date
December 1 2011
Last Update
December 29 2011
Active Locations (1)
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1
Seoul National University Bundang hopital
Seongnam-si, Gyeonggi-do, South Korea, 463-787