Status:
COMPLETED
Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness
Lead Sponsor:
Beth Israel Deaconess Medical Center
Collaborating Sponsors:
American Medical Association
Conditions:
Acute Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of this study is to determine the effect of thiamine therapy on oxygen consumption in critically-ill patients. The investigators will evaluate this by measuring VO2 before and after thia...
Detailed Description
Extensive research has been done over the past two decades looking at the role of oxygen delivery (DO2) and oxygen utilization (VO2) in critical illness. VO2 depends on cardiac output, arterial oxygen...
Eligibility Criteria
Inclusion
- Adult patients (age \> 18 years) admitted to an ICU
- Mechanically ventilated
Exclusion
- Unstable ventilator settings during measurement of VO2
- Temp \> 100 at time of VO2 measurement
- FIO2 \> 60%
- Endotracheal cuff leak, chest tube, or other evident source of air leak
- Thiamine supplementation within 24 hours prior to study enrollment
Key Trial Info
Start Date :
September 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01462279
Start Date
September 1 2011
End Date
October 1 2012
Last Update
January 16 2018
Active Locations (1)
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1
Beth Israel Deaconess Medical Center (BIDMC)
Boston, Massachusetts, United States, 02115