Status:
COMPLETED
L-citrulline Supplementation & Cold Exposure
Lead Sponsor:
Florida State University
Conditions:
Hypertension
Eligibility:
MALE
18-35 years
Phase:
PHASE1
PHASE2
Brief Summary
Cardiovascular disease (CVD) is considered the primary cause of death in the developed world. Large scale epidemiological studies indicate that prevalence of hypertension along with adverse cardiovasc...
Detailed Description
The specific aims of the study are: AIM 1: To determine the acute effects of cold exposure and isometric exercise, on cardiovascular hemodynamics and autonomic regulation. The working hypothesis is t...
Eligibility Criteria
Inclusion
- Men
- Blood pressure lower than 140/90mmHg
- Age 18 to 35 years
- BMI 20-39 kg/m2
Exclusion
- Blood Pressure \>160/100 mmHg
- Asthma
- Glaucoma
- Herpes simplex
- Uncontrolled diabetes
- Neurological disease
- Cardiovascular disease
- Inflammatory disease
- Kidney disease
- Hormone replacement therapy (HRT)
- Amino acid/vitamin supplementation\\
- Corticosteroids or non-steroidal anti-inflammatory drugs
- Any drug known to affect BP or heart rate
- Glycemic control drugs
- Lipids reducing drugs
- Participants should not consume \> 12 alcoholic drink/week
- Smokers
- Regular Exercisers (\>1.5 hour/week).
Key Trial Info
Start Date :
May 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT01462591
Start Date
May 1 2011
End Date
May 1 2012
Last Update
August 5 2014
Active Locations (1)
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1
FSU College of Human Sciences
Tallahassee, Florida, United States, 32306