Status:
COMPLETED
Study EvAluating Genotypes While Using Lucentis 2
Lead Sponsor:
University of California, San Diego
Collaborating Sponsors:
Genentech, Inc.
Conditions:
Age-Related Macular Degeneration
Eligibility:
All Genders
50+ years
Phase:
PHASE4
Brief Summary
The purpose of the study is to investigate whether the efficacy of Lucentis treatment for exudative age-related macular degeneration is associated with VEGF and HTRA1 DNA polymorphisms
Detailed Description
Age-related macular degeneration (AMD) is a progressive disease that causes irreversible visual impairment and blindness in nearly 50 million people globally. Although geographic atrophy and neovascul...
Eligibility Criteria
Inclusion
- Ability to provide written informed consent and comply with the study assessments for the full duration of the study.
- Age \> 50 years.
- Treatment naïve (study eye only) AMD patients that are determined to be candidates for ranbizumab.
- Visual acuity 20/32 to 20/230.
Exclusion
- Pregnancy
- Prior enrollment in the study
- Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated
- Previous therapy in study eye for AMD or other retinal disease which may be used in the treatment of AMD.
- Any other condition that the investigator believes would pose a significant hazard to the subject if on-label ranibizumab were prescribed
- Any participation in another simultaneous medical investigation or trial for AMD \*Concurrent eye disease in the study eye that could compromise visual acuity (e.g., diabetic retinopathy, advanced glaucoma)
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT01464723
Start Date
May 1 2008
End Date
January 1 2013
Last Update
August 14 2019
Active Locations (1)
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1
Shiley Eye Center, University of California, San Diego
San Diego, California, United States, 92093