Status:
TERMINATED
Use of Multiple Brain Imaging Modalities (PET and MRS) to Identify Metabolic Abnormalities in Major Depression
Lead Sponsor:
Paul Carlson
Collaborating Sponsors:
Western Institute for Biomedical Research
University of Utah
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-55 years
Brief Summary
Several lines of evidence support the existence of an underlying abnormality in brain energy metabolism may play a key role in the biology of mood disorders. The current study utilizes two distinct bu...
Eligibility Criteria
Inclusion
- Meet DSM-IV criteria for Major Depressive Disorder (MDD), Recurrent
- Montgomery-Asberg Depression Rating Scale (MADRS) score \> 18
Exclusion
- Any coexisting psychiatric illness other than generalized anxiety disorder, panic disorder, or social/specific phobias
- Any history of substance dependence
- Substance abuse within the past 6 months
- Significant risk of suicide, as defined by score \>4 on item 10 of the MADRS or in the clinical judgment of the study physician
- Any significant medical or neurological condition which is likely to impact the central nervous system and/or affect the results of MRS or PET imaging
- For the subset of unmedicated MDD patients, any psychotropic medications within 4 weeks prior to scanning. For the subgroup of medicated patients, they may be taking a stable dose (i.e., same dose for at least 4 weeks at the time of scanning) of standard antidepressant medications, but may not be taking any other psychotropic medication.
- Inability to give informed consent
- Contraindication to MRI (e.g., pacemaker, ferromagnetic implants in the body)
Key Trial Info
Start Date :
May 15 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 24 2012
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01465165
Start Date
May 15 2011
End Date
June 24 2012
Last Update
May 19 2017
Active Locations (1)
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1
University of Utah Dept of Psychiatry
Salt Lake City, Utah, United States, 84112