Status:
COMPLETED
Treatment of APAP Toxicity With IV and Oral NAC 2008-2011
Lead Sponsor:
Akron Children's Hospital
Conditions:
Acetaminophen Toxicity
Eligibility:
All Genders
1-21 years
Brief Summary
Retrospective chart review of patients who receive N-acetylcysteine for Acetaminophen(APAP) toxicity to assess length of oral vs. IV treatment and the effect of a Clinical Pharmacology and Toxicology ...
Eligibility Criteria
Inclusion
- Admitted to CHMCA between June 1, 2008 to June 30, 2011
- Qualifying ICD-9 diagnosis code for the following APAP overdose situations: poisoning, accidental, suicide attempt, therapeutic use, assault, and undetermined (965.4, E850.4, E950.0, E935.4, E962.0, E980.0)
- Serum APAP concentration above the possible hepatotoxic line on the Rumack-Matthew's nomogram if obtained \> 4 hours post ingestion
- Between ages 0-21 years on date of admission
- Acute APAP ingestion
Exclusion
- Serum APAP concentrations not actually documented
- Did not receive the oral or IV NAC treatment
- Preexisting liver disease such as cirrhosis or hepatitis C
- Patient \> 21 years of age on the date of admission
- Chronic APAP ingestion
Key Trial Info
Start Date :
June 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2011
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT01465542
Start Date
June 1 2011
End Date
November 1 2011
Last Update
July 25 2023
Active Locations (1)
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1
Children's Hospital Medical Center of Akron
Akron, Ohio, United States, 44308