Status:
UNKNOWN
Clinical Testing of a D1 Agonist for Cognitive Enhancement in Schizotypal Personality Disorder
Lead Sponsor:
Larry J. Siever
Collaborating Sponsors:
New York State Psychiatric Institute
Conditions:
Cognitive Impairments
Schizotypal Personality Disorder
Eligibility:
All Genders
18-60 years
Phase:
PHASE2
Brief Summary
Currently, no study to date has directly tested a selective D1R agonist in relation to the cognitive impairment of Schizophrenia without the confound of neuroleptics. The investigators propose to exam...
Detailed Description
Working memory deficits are central to the cognitive impairment of schizophrenia and other psychiatric disorders. The D1 receptor (D1R) is probably the best established mediator of working memory in n...
Eligibility Criteria
Inclusion
- Currently meeting DSM-IV-TR criteria for Schizotypal Personality Disorder
- Males and Females 18 ≤ age ≤ 60
- Medically and neurologically healthy
- Willing and having capacity to provide informed consent
Exclusion
- Currently bipolar I disorder, schizophrenia or current psychosis
- Clinically significant cardiovascular or neurological conditions, uncontrolled hypertension, clinically significant EKG abnormalities, or serious general medical illness
- Clinical evidence of dehydration or significant hypotension
- Currently meeting DSM-IV-TR criteria for Major Depressive Disorder
- Current substance abuse or past dependence within the last six months (other than nicotine)
- Currently taking psychotropic medications
- Currently pregnant or lactating
- Non-English speaking
- Socio-economically disadvantaged people will be included in our research study.
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2013
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01466205
Start Date
January 1 2011
End Date
January 1 2013
Last Update
July 20 2012
Active Locations (1)
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1
Mount Sinai School of Medicine
New York, New York, United States, 10029