Status:
COMPLETED
Urinary Excretion of Acetylamantadine by Normal Healthy Volunteers
Lead Sponsor:
University of Manitoba
Collaborating Sponsors:
St. Boniface Hospital
Conditions:
Healthy Metabolism
Eligibility:
All Genders
18-69 years
Phase:
NA
Brief Summary
Amantadine appears to be a specific substrate for acetylation by spermidine/spermine N1-acetyltransferase (SSAT). SSAT activity in cancer cells is higher by several-fold compared to normal cells. Aman...
Detailed Description
A group of 20 female and 20 male normal healthy volunteers ages 18 to 69 will be recruited from the community by use of a general advertisement placed initially as posters. We will tell the volunteer...
Eligibility Criteria
Inclusion
- Normal Healthy Volunteers (20 female and 20 male)
- Ages 18-69
Exclusion
- Previous adverse reaction of amantadine
- Pregnant or lactating females
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01467258
Start Date
November 1 2011
End Date
April 1 2012
Last Update
July 29 2013
Active Locations (1)
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1
St. Boniface General Hospital
Winnipeg, Manitoba, Canada, R2H 2A6