Status:
COMPLETED
N-Acetylcysteine for Neuroprotection in Parkinson's Disease
Lead Sponsor:
Weill Medical College of Cornell University
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Parkinson Disease
Eligibility:
All Genders
50-75 years
Phase:
PHASE1
PHASE2
Brief Summary
The overall objective of this developmental/exploratory study is to use noninvasive proton magnetic resonance spectroscopy (1H MRS) to assess (a) whether brain levels of the antioxidant glutathione (G...
Detailed Description
Parkinson's disease (PD) is a neurodegenerative disorder in which deficits of the primary intracellular antioxidant, glutathione (GSH), are postulated to mediate increased oxidative stress and mitocho...
Eligibility Criteria
Inclusion
- Diagnosis of idiopathic PD according to the United Kingdom Parkinson's Disease Society Brain Bank criteria (UKPDSBB) criteria (only for PD group
- Age 50 to 75 years
- Able to give informed consent for study participation
- Not on any medication for PD (anticholinergic agents allowed)
Exclusion
- Unable to give informed consent
- Unable to undergo a brain MRI
- PD duration ≥15 years
- Receiving dopamine receptor blocking agents, including typical neuroleptics, prochlorperazine, and metoclopramide
- Diagnosis of major depression or other axis I psychopathology
- Modified Mini-Mental Status Exam (MMSE) ≤ 24/30
- Diagnosis of chronic or persistent illnesses that could affect oxidative stress status, such as diabetes or congestive heart failure
- Significant concomitant medical disease limiting life expectancy to less than 12 months from study inclusion
- Diagnosis of primary mitochondrial disorder, epilepsy, stroke, multiple sclerosis or other neurodegenerative diseases such as Alzheimer's disease or ALS
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2016
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01470027
Start Date
January 1 2012
End Date
August 1 2016
Last Update
August 28 2018
Active Locations (1)
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1
Weill Cornell Medical College
New York, New York, United States, 10021