Status:
UNKNOWN
Mechanisms Underlying Postoperative Insulin Resistance and Inflammation
Lead Sponsor:
University of Nottingham
Conditions:
Obesity
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
Having an operation places an enormous burden on the body, leading to the development of inflammation and so called 'insulin resistance'. Insulin resistance means the body is unable to respond to impo...
Detailed Description
Interested participants who are undergoing abdominal (tummy) surgery will be recruited from surgical clinics. They will be asked to attend the Greenfield Human Physiology Laboratory where they will be...
Eligibility Criteria
Inclusion
- Age 18-75 yrs
- Correct BMI and waist circumference criteria : Obese group - BMI ≥30 AND waist circumference ≥94 cm in men and ≥ 80 cm in women, Non obese group - BMI 18.5-25 AND waist circumference ≤94cm in men and ≤80 cm in women Due to undergo elective major abdominal surgery ASA I-III Caucasian patients Able to give informed consent and comply with study protocol
Exclusion
- History of significant preoperative weight loss (\>10% over preceding 3 weeks)
- Clinical history of pulmonary aspiration
- Known gastro-oesophageal reflux disease (GORD) or hiatus hernia
- History of difficult intubation or conditions leading to the latter such as: previous neck radiotherapy/rheumatoid arthritis/presence of thyroid goitre
- Metabolic disorders (e.g. diabetes mellitus, thyroid disease, Cushing's Syndrome)
- Simultaneous participation in another clinical study or involvement in a clinical study within the preceding 3 months,
- Patients with suspicion of alcohol/drug abuse
- Pregnancy
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2012
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT01470534
Start Date
November 1 2011
End Date
November 1 2012
Last Update
October 5 2012
Active Locations (1)
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1
University of Nottingham
Nottingham, United Kingdom, NG7 2UH