Status:
COMPLETED
Regenerative Medicine in Ocular Surface: Application of Cell Therapy for Ocular Surface Repair Using Progenitor Cells of Sclerocorneal Limbus Amplified ex Vivo
Lead Sponsor:
Fundacion Clinic per a la Recerca Biomédica
Conditions:
Unilateral Limbic Insufficiency
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Progenitor limbo sclerocorneal cells have properties of proliferation and differentiation to corneal and conjunctival epithelium. This cells can be isolated and ex vivo expanded using cell culture tec...
Eligibility Criteria
Inclusion
- principal
- Serious unilateral limbic insufficiency
- Normal ophthalmological clinical examination in the opposite eye (biopsied eye)
Exclusion
- one-eyed
- serious disorders in palpebral dynamics
- bilateral limbic insufficiency, immunological, systemic or local illness like toxical epidermic necrosis or pemphigoid
- breastfeeding or pregnancy
- positive serology of HIV, VLTH, HVC, HVB, CMV, Trypanosoma Cruzi or Treponema Pallidum
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01470573
Start Date
November 1 2011
End Date
December 1 2012
Last Update
December 10 2012
Active Locations (3)
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1
Instituto Universitario Barraquer
Barcelona, Barcelona, Spain, 08021
2
Instituto de Microcirugía Ocular
Barcelona, Barcelona, Spain, 08035
3
Hospital Clinic of Barcelona
Barcelona, Barcelona, Spain, 08036