Status:
UNKNOWN
Characterization of the Changes in the Signalling Pathways During Spinal Cord Injury-induced Skeletal Muscle Atrophy
Lead Sponsor:
Clinique Romande de Readaptation
Collaborating Sponsors:
Swiss Paraplegic Research, Nottwil
Conditions:
Spinal Cord Injuries
Muscle Atrophy
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Atrogin-1 and muscle RING finger-1 are skeletal muscle specific genes, with ubiquitin ligase activities, that are upregulated during muscle atrophy in mice. The Akt/GSK3 and Akt/mTOR pathways are invo...
Detailed Description
Measures: For each group, the muscle biopsies will be divided into 3 samples which will be used for a) real-time PCR to quantify the gene expression of the different components of the ubiquitin-prote...
Eligibility Criteria
Inclusion
- acute, motor complete SCI
- lesion level C5-T12
Exclusion
- diabetes type I
- pregnancy
- oral anti-coagulation
- osteosyntheses of the femur
- hepatitis B,C or D
- HIV
Key Trial Info
Start Date :
May 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2015
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT01470950
Start Date
May 1 2010
End Date
December 1 2015
Last Update
February 5 2015
Active Locations (2)
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1
Swiss Paraplegic Centre
Nottwil, Canton of Lucerne, Switzerland, 6207
2
Clinique Romande de Réadaption
Sion, Valais, Switzerland, 1951