Status:
COMPLETED
Effects of HBO Therapy on Muscular Insulin Resistence in Type 2 Diabetes
Lead Sponsor:
German Diabetes Center
Collaborating Sponsors:
Heinrich-Heine University, Duesseldorf
Conditions:
Obesity
Non-insulin-dependent Diabetes Mellitus
Eligibility:
All Genders
30-70 years
Phase:
NA
Brief Summary
Hyperbaric oxygen therapy (HBO) is applied for several diseases. The effect on insulin sensitivity is yet unknown. Hypothesis: HBO therapy improves insulin sensitivity in patients.
Detailed Description
HBO therapy is applied to improve wound healing in diabetic patients with foot ulcera. However, it might induce oxidative stress as well as improve antioxidative capacity. The effects on insulin sensi...
Eligibility Criteria
Inclusion
- Aged ≥ 30 years- ≤ 70 years
- Balanced sex (50: 50)
- BMI 20- 25 kg/m 2 normal- weight group
- BMI 35- 39,9 kg/m 2 (Obese typ II)
Exclusion
- Acute illness 2 weeks before start of examination
- Autoimmune or Immune disorder deseases (Leukozyten \< 5000/µl
- Renal insufficiency (Kreatin \> 1,5 mg/dl)
- Heart disease, condition after heart attack
- Anemia (Hb \<12g/l, contolled before every day of eximination) or blood donations 4weeks before eximinatin.
- Participation in another trial within the last 2 weeks
- Pharmacological- immuno therapy (Cortisol, Antihistaminika, ASS)
- Thyroid disorders
- Glitazone or Insulin- Therapy
- Pragnancy, Lactation, Menstruation
- Smoking cigaretts, Alcohol- and drug abuse
- Psychiatric disorders
- Risk for/ or diagnosed HIV/ AIDS or Hepatitis B/C
- Liver disease, which are not caused by non- alcoholic steato- hepatitis
- Working on night shifts or irregular rhythem of night- day
- Impaired wound healing or clotting disorders
- Allergic reaction to local anesthetics
- Malignant cancer
Key Trial Info
Start Date :
March 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01472328
Start Date
March 1 2012
End Date
August 1 2015
Last Update
June 13 2023
Active Locations (1)
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1
German Diabetes Center
Düsseldorf, Germany, 40225