Status:
COMPLETED
Urinary 8-isoprostane is Elevated in Acute Childhood Asthma
Lead Sponsor:
Stony Brook University
Conditions:
Childhood Asthma
Oxidative Stress
Eligibility:
All Genders
4-18 years
Brief Summary
Oxidative stress is seen in children with asthma, but is hard to measure. The investigators exploring the utility of using a commercially available assay to measure oxidative stress in the urine in as...
Eligibility Criteria
Inclusion
- Group 1
- Patients aged 4-18 years
- Known stable asthmatics on no medications or with no medication changes in 3 weeks prior to enrollment
- No asthma hospitalizations in past 3 months
- Parent available to consent
- Group 2
- Patients aged 4-18
- Known asthmatic, admitted to Stony Brook University Hospital for status asthmaticus
- Parent available to consent
Exclusion
- Any child with documented fever within 24 hours of study entry
- Any child with a known current history of tracheo- or bronchomalacia
- Any child with known clinical or laboratory evidence of shock (see below)
- Any child with history of documented immunodeficiency, rheumatologic disease, cystic fibrosis, or renal dysfunction (see below)
- Any child with a current or recent (less than 1 year) history of tracheostomy
- Any child with a known genetic abnormality
- Any pregnant child
- Any child with a history of autism
- Any child whose parent/caregiver is unable to give informed consent
Key Trial Info
Start Date :
November 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT01472471
Start Date
November 1 2010
End Date
February 1 2012
Last Update
June 6 2013
Active Locations (1)
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1
Long Island Children's Hospital at Stony Brook
Stony Brook, New York, United States, 11794-8111