Status:
COMPLETED
Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting
Lead Sponsor:
Sergio Bergese
Conditions:
Postoperative Nausea and Vomiting (PONV)
Nausea
Eligibility:
All Genders
18-85 years
Phase:
PHASE4
Brief Summary
This study is being done to determine the efficacies of two preventative drug combinations for postoperative nausea and vomiting in patients undergoing neurosurgery. The aim of this study is to compar...
Detailed Description
One hundred-seventy-six (200) consecutive patients meeting the inclusion and exclusion criteria and who give written informed consent to participate in the study will be randomly assigned to one of tw...
Eligibility Criteria
Inclusion
- Adult patients
- 18 to 85 years of age
- Scheduled for neurosurgery requiring opening of the cranium and dura at Ohio State University Medical Center and who consent in writing to participate in this study are eligible.
Exclusion
- Patients will be excluded from this study if they are
- prisoners
- pregnant women
- mentally ill
- under the age of 18 or over the age of 85
- American Society of Anesthesiologist (ASA) classification V
- alcohol or drug abusers
- have a cerebral perfusion pressure (CPP) greater than 150 mmHg or less than 50 mmHg.
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2013
Estimated Enrollment :
122 Patients enrolled
Trial Details
Trial ID
NCT01474915
Start Date
June 1 2007
End Date
April 1 2013
Last Update
December 3 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States, 43210