Status:
COMPLETED
Regulatory Lymphocytes in Patients Treated With Specific Immunotherapy
Lead Sponsor:
Ministry of Science and Higher Education, Poland
Conditions:
Immunotherapy
Seasonal Allergic Rhinitis
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether specific subcutaneous immunotherapy affects fractions of regulatory T lymphocytes and histamine H2 receptor expression and ZAP70 in regulatory T lymph...
Detailed Description
Allergy constitutes an important problem worldwide thus effective treatment is crucial for the reduction of symptoms severity, patients' activity and quality of life as well as for the reduction of di...
Eligibility Criteria
Inclusion
- seasonal allergic rhinitis with or without allergic conjunctivitis
- sensitization to grass pollen allergens (confirmed with skin prick tests, conjunctival provocation test, specific IgE)
- symptoms of allergic rhinitis with or without conjunctivitis for at least 2 years before the study
Exclusion
- sensitization to allergens, that could interfere with grass pollen
- asthma
- cystic fibrosis
- ciliary dysmotility syndrome
- bronchiectasis
- smoking
- tuberculosis
- neoplastic disease
- chronic sinusitis and nasal polyps
- systemic glucocorticosteroids treatment
- treatment with immunotherapy in the past
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT01475188
Start Date
March 1 2007
End Date
December 1 2010
Last Update
November 21 2011
Active Locations (1)
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1
Department of Pneumonology and Allergy, Medical University of Lodz
Lodz, Poland, 90-153