Status:
COMPLETED
Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Coronary Artery Disease
Valvular Heart Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Anesthesia practice in the 21st century is increasingly outcomes-oriented and evidence-based, but there remain significant gaps in our knowledge, even for commonly-encountered clinical situations. Cur...
Detailed Description
Current evidence supports the superiority of sevoflurane for myocardial protection during cardiac surgery when compared to total intravenous anesthesia with propofol. However, there is no evidence to ...
Eligibility Criteria
Inclusion
- Patients must be 18 years or over (There is no upper age limit to enrollment)
- Eligible procedures are: CABG on-pump or off-pump, single valve repair/replacement, or CABG/single valve combined procedures
Exclusion
- Cardiac surgeries that are not one of the included cases
- Planned extubation in the operating room
- Patients refusing blood products (vis à vis blood sampling)
- Pregnant patients
- Malignant hyperthermia or documented/stated allergy to potent volatile anesthetic agents
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
464 Patients enrolled
Trial Details
Trial ID
NCT01477151
Start Date
November 1 2011
End Date
March 1 2015
Last Update
June 8 2015
Active Locations (1)
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1
University Hospital - London Health Sciences Centre
London, Ontario, Canada, N6A5A5