Status:
COMPLETED
Improved Patient Recovery After Anesthesia
Lead Sponsor:
University of Utah
Conditions:
Recovery From Anesthesia
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
The proposed study will measure the incidence of adverse events and the decrease in time to meet discharge criteria from the post anesthesia care unit when hypercapnic and hyperpnoea are used during e...
Detailed Description
Hypercapnia has been used in conjunction with hyperpnoea to provide a more rapid return of responsiveness after inhaled anesthesia. The benefits of accelerating patient recovery in the operating room ...
Eligibility Criteria
Inclusion
- adult ASA class I-III subjects of both genders scheduled to undergo eye surgery at the Moran Hospital.
Exclusion
- a history of renal or hepatic disease, chronic alcohol or drug abuse, disabling neuropsychiatric disorder, hypersensitivity, or unusual response to other halogenated anesthetics, pulmonary hypertension, increased intracranial pressure, seizure disorder, or personal/familial history of malignant hyperthermia, and current smokers.
- Subjects will also be excluded if they are currently being treated with known hepatic enzyme-inducing drugs (e.g., phenobarbital, dilantin, or isoniazid) or with drugs known to alter anesthetic requirements (e.g., opiates, clonidine, alpha2 agonists, alcohol, anticonvulsants, antidepressants, barbiturates, benzodiazepines or other tranquilizers).
- Subjects will also be excluded if they have intolerance to non-steroidal anti-inflammatories.
- In addition subjects who have received general anesthesia within the previous 7 days, received any investigational drug within the previous 28 days, or participated in a previous isoflurane or desflurane study will be excluded.
- Female subjects can be neither pregnant nor breast feeding.
- Subjects with significant restrictive lung disease will also be excluded.
- Subjects passing these criteria will be further evaluated with a medical history including medications, abbreviated physical examination, clinical laboratory tests (urine drug test), and a urine or serum human chorionic gonadotropin pregnancy test for women with childbearing potential.
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2011
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT01477398
Start Date
April 1 2010
End Date
April 1 2011
Last Update
August 22 2016
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