Status:
WITHDRAWN
ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia
Lead Sponsor:
Altor BioScience
Collaborating Sponsors:
M.D. Anderson Cancer Center
Conditions:
Acute Myeloid Leukemia
Eligibility:
All Genders
2-59 years
Phase:
PHASE1
Brief Summary
This is a single-center open-label phase I clinical trial of delivering haploidentical natural killer (NK) cells matured ex vivo with ALT-801 followed by intravenous infusions of ALT-801 in patients w...
Detailed Description
Hematopoietic stem cell transplantation (SCT) is an effective treatment for acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). For patients transplanted in first remission or with low ri...
Eligibility Criteria
Inclusion
- Recipient
- Patients with relapsed AML, including those with CNS disease or previous hematopoietic stem cell transplantation, or primary refractory AML (primary AML that has failed remission to at least two cycles of induction therapy)
- For patients of Cohorts 2 to 4, availability of a haploidentical family peripheral blood stem cell donor selected for best possible KIR reactivity
- Patient is between 2 and 59 years of age, inclusive
- Patient must have recovered from the treatment-related toxicities of prior cytotoxic agents received in the 4 weeks prior to beginning treatment on this protocol, with the exception of cytopenias resulting from persistent disease, and alopecia
- Zubrod performance scale (Refer to Appendix C) ≤ 2 or Lansky (Refer to Appendix D) \> 60
- Adequate renal function defined as:
- For adults serum creatinine \< 2 mg/dL
- For children serum creatinine \< 2 mg/dL or \< 2 times upper limit of normal (ULN) for age (which ever is less) If abnormal creatinine level, 24h creatinine clearance \> 60 mL/min/1.73m\^2
- Adequate liver function, defined as: Total bilirubin ≤ 2 mg/dL and SGPT (ALT) ≤ 2.5 x ULN for age (unless Gilbert's disease or abnormal liver function due to primary disease)
- Pulmonary symptoms controlled by medication and pulse oximetry\> 92% room air
- New York Heart Association classification \< III
- Negative serum test to rule out pregnancy within 2 weeks prior to registration in females of childbearing potential (non childbearing potential defined as premenarchal, greater than one year post-menopausal, or surgically sterilized)
- Sexually active males and females of childbearing potential must agree to use a form of contraception considered effective and medically acceptable by the Investigator
- Negative serology for human immunodeficiency virus (HIV)
- Recipient
Exclusion
- Investigational therapies in the 4 weeks prior to beginning treatment on this protocol
- Congestive heart failure \< 6 months prior to screening
- Unstable angina pectoris \< 6 months prior to screening
- Myocardial infarction \< 6 months prior to screening
- Donor Inclusion Criteria:
- Related to recipient (sibling, parent, offspring, offspring of a sibling)
- HLA-haploidentical to recipient (need not be re-tested if already performed previously, provided copies of the original results are available)
- Able and willing to undergo apheresis
- Willing to donate blood for baseline chimerism assessment
- Negative serum test to rule out pregnancy within two weeks prior to registration in females of childbearing potential (non childbearing potential defined as premenarchal, greater than one year post-menopausal, or surgically sterilized)
- Donor must meet institutional eligibility criteria for allogeneic blood stem cell donation including infectious disease screening panel (Hepatitis B, Hepatitis C, HIV, CMV, and West Nile Virus) and CBC, differential and platelet studies
- Donor must meet stem cell donor eligibility criteria as set forth in 21 CFR 1271 subpart C
- The preferred Donor will be selected as the most alloreactive of the available haploidentical related donors on the basis of predicted NK cell alloreactivity using Recipient and Donor HLA type. If necessary, the best of equally alloreactive donors will be determined by Donor KIR type. NK alloreactivity is defined as o A KIR gene is present on the Donor NK cells for which
- the HLA haplotype (KIR ligand) for the KIR receptor in question is absent in the Recipient, and
- the HLA haplotype (KIR ligand) for the KIR receptor in question is present in the Donor
- Donor
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01478074
Start Date
November 1 2011
End Date
November 1 2013
Last Update
January 3 2014
Active Locations (1)
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1
MD Anderson Cancer Center
Houston, Texas, United States, 77030